ATX-Red AR-2 - 50 ug

ATX-Red AR-2 is an in vivo imaging probe for visualizing and measuring ATX activity. It is an analog of the autotaxin substrate lysophosphatidylcholine (LPC) and contains a near-infrared fluor (Licor IRDye® 800CW) and quencher (Licor IRDye® QC-1). The design is modeled after FS-3 a fluorogenic ATX substrate that is predictive of ATX activity. In the parent compound fluorescence is quenched through intramolecular energy transfer but when autotaxin cleaves ATX-Red AR-2 fluorescence increases. This activation mechanism is specific to autotaxin in vitro and in vivo.Autotaxin which has lysophospholipase D (lysoPLD) activity cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA) a potent mitogen that as been implicated in the pathophysiology of ovarian cancer. LysoPLD/ATX has been demonstrated to increase cell motility neovascularization proliferation and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung glioma