AS1938909 (SHIP2 Inhibitor) - 5 mg

AS1938909 is a potent SHIP2 inhibitor (Ki = 0.44uM). This compound shows signficant selectivity over some related phosphatases (IC50 = 0.18uM 21uM >50uM for mSHIP2 hSHIP2 hPTEN respectively). It also enhances Akt phosphorylation and increases glucose consumption and uptake in L6 myotubes.ReferencesA Suwa T Yamanoto et al. "Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes" Eur J Pharmaco 2010 642 177