ARN14988 (aCDase Inhibitor) - 5 mg

Acid ceramidase (aCDase) is a lysosomal amidase which hydrolyzes the acyl chain from ceramides forming sphingosine which is subsequently phosphorylated to the bioactive lipid sphingosine 1-phosphate. aCDase is upregulated in many cancer types such as melanoma prostate head neck and colon cancers. ARN14988 is a potent inhibitor of aCDase in vitro (IC50 = 12 nM) and in A375 melanoma cells (IC50 = 1.5uM). ARN14988 is weakly cytotoxic by itself but shows a synergystic effect with some common anti-cancer drugs (5-Fluorouracil vemurafinib and taxol) in proliferative G361 cells.