Apamin bee venom (SS1-11 SS3-15) - 1 mg

CAS Number: 24345-16-2Molecular Weight: 2029.93Salt Form: AcetatePurity: >96%Sequence (3-letter): Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Cys1-Cys11 Cys3-Cys15)Sequence (1-letter): CNCKAPETALCARRCQQH-NH2Storage: -20 °C or belowSolubility: water to 1 mg/mLApamin is a peptide toxin found in bee venom that is known to cross the blood-brain barrier. Apamin potently blocks ATP-type Ca+2-activated K+ channels SK1 SK2 and SK3 (low nM to sub-nM IC50) but is inactive against SK4. Apamin is used to elucidate the roles of SK channels in neurons and some cancer cells. It is a globular peptide with disulfide bridges between Cys1-Cys11 (SS1-11) and Cys3-Cys15 (SS3-15).References1. Blatz A.L. and Magleby K.L. (1986) “Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle” Nature 323: 718 – 720.2.Burnham M.P. et al. (2002) “Characterization of an apamin-sensitive small-conductance Ca2+-activated K+ chan