Anti-PtdIns(3 4 5)P3 IgM In Ascities - 500 ug

Anti-PtdIns(3 4 5)P3 is an IgM monoclonal antibody in ascites.Subclass: IgMSource: MouseApplications: ImmunofluorescenceSpecificity: Anti-PtdIns(3 4 5)P3 IgM in ascities has been shown to recognize PtdIns(3 4 5)P3 in murine and human cells. Cross reactivity is 1% orless with other phosphatidylinositol phosphates or lipids.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2.Product keywords: PIP3 PI(3 4 5)P3 PtdIns(3 4 5)P3 IgM anti-PIP3