AG-490 - 5 mg

Activity: JAK-2 inhibitor . Function/Pharmacology: A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4. Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N¬-(phenylmethyl)-2-propenamide