Ac-YVAD-CHO Caspase 1 (ICE) Inhibitor - 5 mg

CAS Number: 143313-51-3Molecular Weight: 492.22Salt Form: N/APurity: >95%Sequence (3-letter): Ac-Tyr-Val-Ala-Asp-CHOSequence (1-letter): Ac-YVAD-CHOStorage: -20 °C or belowSolubility: DMSO (5 mg/ml) water (5 mg/ml) ethanol (30 mg/ml) DMF (30 mg/ml)N-Ac-Tyr-Val-Ala-Asp-CHO (Ac-YVAD-CHO) is a synthetic peptide that reversibly and selectively inhibits interleukin-1β converting enzyme (ICE; Caspase-1). Caspase-1 is a pro-inflammatory cytokine and like other caspase inhibitors interferes with the initiation of apoptosis and has numerous possible clinical applicationsReferences1. Cerretti D.P. et al. (1992) “Molecular cloning of the interleukin-1 beta converting enzyme” Science 256: 97–100.2.Thornberry N.A. et al. (1992) “A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes” Nature 356: 768–774.