Ac-Val-Glu-Ile-Asp-AMC (Caspase 6 (Mch2) Substrate) - 5 mg

CAS Number: 219137-97-0Molecular Weight: 673.72Salt Form: N/APurity: >95%Sequence (3-letter): Ac-Val-Glu-Ile-Asp-AMCSequence (1-letter): Ac-VEID-AMCStorage: -20 °C or belowSolubility: DMSO phosphate buffer pH 7.5Ac-VEID-AMC is a fluorogenic substrate for caspase 6 (Mch-2α) a member of the cysteine-aspartate protease family which play a central role in the execution-phase of apoptosis. The excitation/emission maximum of AMC is 340-360/440-460 nm respectively. Ac-VEID-AMC is based on lamin A site of cleavage.References1. Benford H.L. et al. (2001) “Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro” 28 (5): 465–473.2. Rouaux C. e al. (2003) “Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration” EMBO J. 22 (24): 6537–6549.