Ac-Val-Gln-Val-Asp-pNA (Caspase 3 Substrate) - 25 mg

Molecular Weight: 621.28 Salt Form: N/A Purity: >96% Sequence (3-letter): Ac-Val-Gln-Val-Asp-pNA Sequence (1-letter): Ac-VQVD-pNA Storage: -20 °C or belowAc-Val-Gln-Val-Asp-pNA is a colorimetric Caspase 3 substrate. Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer’s disease and proposed as a target for drug discovery.Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm.