Ac-Val-Asp-Val-Ala-Asp-CHO (Caspase 2 (ICH-1) Inhibitor) - 5 mg

CAS Number: 194022-51-0Molecular Weight: 543.25Salt Form: N/APurity: >95%Sequence (3-letter): Ac-Val-Asp-Val-Ala-Asp-CHO (aldehyde)Sequence (1-letter): Ac-VDVAD-CHOStorage: -20 °C or belowAc-Val-Asp-Val-Ala-Asp-CHO is a reversible peptidyl aldehyde inhibitor of caspase 2. Caspase 2 part of the ICH-1 sub-family is a cysteine protease with a poorly defined role in apoptosis. It associates with several apoptotic proteins such as death effector filament-forming Ced-4-like apoptosis protein (DEFCAP) RIP-associated Ich-1/Ced-3-homologue protein with a death domain (RAIDD) and apoptosis repressor with caspase recruitment domain (ARC). Caspase 2 can be activated by the PIDDosome formed by the association of PIDD1 and CRADD. Recent work demonstrates that Caspase-2 resides in the mitochondria and is essential for stress-induced apoptosis. Caspase-2 cleaves at an Asp residue with a preferred sequence of Val-Asp-Val-Ala-Asp-X.