Ac-Val-Asp-Gln-Gln-Asp-pNA (Caspase 2 (ICH-1) Substrate) - 5 mg

Molecular Weight: 765.29Salt Form: TFAPurity: >96%Sequence (3-letter): Ac-Val-Asp-Gln-Gln-Asp-pNASequence (1-letter): Ac-VDQQD-pNAStorage: -20 °C or belowAc-Val-Asp-Gln-Gln-Asp-pNA is a colorimetric substrate for Caspase 2. Caspase 2 part of the ICH-1 sub-family is a cysteine protease with a poorly defined role in apoptosis. It associates with several apoptotic proteins such as death effector filament-forming Ced-4-like apoptosis protein (DEFCAP) RIP-associated Ich-1/Ced-3-homologue protein with a death domain (RAIDD) and apoptosis repressor with caspase recruitment domain (ARC). Caspase 2 can be activated by the PIDDosome formed by the association of PIDD1 and CRADD. Recent work demonstrates that Caspase-2 resides in the mitochondria and is essential for stress-induced apoptosis.Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm.