Ac-Leu-Glu-Val-Asp-AFC (Caspase 4 (ICH-2) Substrate) - 5 mg

CAS Number: 1092077-23-0Molecular Weight: 727.27Salt Form: N/APurity: >96%Sequence (3-letter): Ac-Leu-Glu-Val-Asp-AFCSequence (1-letter): Ac-LEVD-AFCStorage: -20 °C or belowAc-LEVD-AFC is a fluorogenic substrate for caspase 4. Caspase 4 is a cysteine protease with a poorly defined role in the caspase family. Recent studies have shown it to have a role in inflammation and innate immunity. Like all caspases it cleaves at the Asp residue and prefers the sequence Leu-Glu-Val-Asp.Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.