Ac-Ile-Glu-Pro-Asp-AMC (Caspase 8/Granzyme B Substrate) - 25 mg

CAS Number: 216757-33-4Molecular Weight: 671.28Salt Form: N/APurity: >96%Sequence (3-letter): Ac-Ile-Glu-Pro-Asp-AMCSequence (1-letter): Ac-IEPD-AMCStorage: -20 °C or belowAc-Ile-Glu-Pro-Asp-AMC is a fluorogenic substrate for caspase-8 and granzyme B. Caspase 8 is a cysteine protease involved in apoptosis induced by Fas and other stimuli. It is an attractive therapeutic target for a variety of degenerative disorders. Granzyme B is a serine protease found in cytotoxic T-cells and NK cells. It cleaves and activates a number of caspases involved in apoptosis.Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.