Ac-DEVD-CHO Caspase 3 (Apopain) Inhibitor - 5 mg

CAS Number: 184179-08-6Molecular Weight: 502.19Salt Form: N/APurity: >95%Sequence (3-letter): Ac-Asp-Glu-Val-Asp-CHOSequence (1-letter): Ac-DEVD-CHOStorage: -20 °C or belowSolubility: 13.7 mg/ml in DMSOCaspase-3 (Apopain) is commonly activated by numerous death signals and cleaves a variety of important cellular proteins and is essential for brain development. Ac-DEVD-CHO is a potent reversible inhibitor of caspase-3 (Ki < 1nM for purified caspase-3) and also inhibits caspase-7 (Ki = 1.6 nM) as well as other caspases to a lesser extent.References1. Talanian R.V. et al (1997) “Substrate Specificities of Caspase Family Proteases” 272 (15): 9677–9682.2. Godinat A. et al. (2013) “A Biocompatible in Vivo Ligation Reaction and Its Application for Noninvasive Bioluminescent Imaging of Protease Activity in Living Mice” ACS Chemical Biology 8 (5): 987-999.