a-Secretase Substrate - 5 mg

Molecular Weight: 2116.1Salt Form: TFAPurity: >96%Sequence (3-letter): Ac-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(Dabcyl)-Arg-OHSequence (1-letter): Ac-RE(EDANS)VHHQKLVFK(Dabcyl)R-OHStorage: -20 °C or belowa-Secretase Substrate is an internally quenched fluorogenic peptide containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP). Cleavage occurs at the Lys-Leu bond and fluorescence can be measured at 490 nm.Komano H Seeger M Gandy S Wang GT Krafft GA Fuller RS. Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast. J Biol Chem. 1998 Nov 27;273(48):31648-51. doi: 10.1074/jbc.273.48.31648. PMID: 9822624