BT2 - 10 mg

Activity: BCKDC kinase inhibitor . Function/Pharmacology: BT2 is an inhibitor of the mitochondrial branched-chain α-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM.1 Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 has also been shown to be a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.2 Chemical Name: 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid