BML-277 - 5 mg

Activity: CHK2 inhibitor . Function/Pharmacology: Potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 µM, demonstrating the selectivity1. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0 – 7.6 µM). Chemical Name: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide