AZD7648 - 25 mg

Activity: DNA-PK inhibitor/CRISPR enhancer . Function/Pharmacology: AZD7648 is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2; cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5. Chemical Name: 7-Methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridine-6-yl)amino]-9-(oxan-4-yl)purin-8-one