Asunaprevir - 5 mg

Activity: HCV NS3 protease inhibitor/CRISPR enhancer . Function/Pharmacology: Asunaprevir is a potent hepatitis C virus NS3 protease inhibitor (IC50 = 0.2 – 3.5 nM).1 Asunaprevir was used as part of a repressible Cas9 system (small molecule-assisted shut off – SMASh) capable of degrading newly synthesized Cas9 protein rapidly to precisely control gene editing.2,3 The Asunapreivr/SMASh system has also been using to target endogenous PD-1 protein for proteasomal degradation.4 Chemical Name: tert-Butyl N-[(2S)-1-[(2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yl)oxy-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]carbamoyl]pyrrolidine-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate