AS-605240 - 5 mg

Activity: PI 3-Kinase inhibitor . Function/Pharmacology: Potent and selective inhibitor of PI 3-kinase  (PI 3-K ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-K and PI 3-K and 7.5-fold selectivity over PI 3-K1. Suppresses joint inflammation in two distinct mouse models1. Ameliorates surgical brain injury2, colitis3, intimal hyperplasia-induced inflammatory processes4 and renal injury/fibrosis5 in rodent models. Orally active. Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione