Aphidicolin - 1 mg

Activity: DNA polymerase inhibitor . Function/Pharmacology: Aphidicolin specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at early S phase while allowing continued cell growth2. Potentiates apoptosis induction induced by other agents3. Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-24. Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol