AOH1996 - 25 mg

Activity: PCNA inhibitor . Function/Pharmacology: AOH1996 inhibits proliferating cell nuclear antigen (PCNA), an enzyme critical to DNA replication and repair processes.1 It enhances the interaction between PCNA and RPB1 subunit of RNA polymerase II leading to degradation of RPB1 and collapse of DNA replication forks in transcribed chromatin regions, thus increasing transcription replication stress causing genomic instability and lethal DNA damage. AOH1996 alone or in combination with topoisomerase inhibitor CPT-11 significantly reduced tumor burden in mice with xenograft tumors (neuroblastoma, breast, or small cell lung cancers) with no side effects. Orally bioavailable. Chemical Name: N-[2-[2-(3-Methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide