Ac-Ala-Glu-Val-Asp-CHO (Caspase 3 Inhibitor) - 5 mg

CAS Number: 184179-08-6Molecular Weight: 458.2Salt Form: N/APurity: >95%Sequence (3-letter): Ac-Ala-Glu-Val-Asp-CHO (aldehyde)Sequence (1-letter): Ac-AEVD-CHOStorage: -20 °C or belowAc-Ala-Glu-Val-Asp-CHO is a reversible aldehyde inhibitor of caspase 3. Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and cleaves several substrates including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer’s disease and proposed as a target for drug discovery.