ABT-869 - 5 mg

Activity: Dual VEGFR and PDGFR kinase inhibitor . Function/Pharmacology: ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 and 14 nM for VEGFR1, VEGFR2, FLT3, PDGFRβ, CSF-1R and KIT respectively.1,2 Protects cells from necroptosis and rescues SIRS mice from TNF-α-induced shock and death.3 Exerts anti-obesity effects by promoting adipocyte browning.4 Inhibits angiogenesis.5 Chemical Name: 1-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea