2E151 - 10 mg

Activity: Vaccine co-adjuvant . Function/Pharmacology: Vaccine adjuvants are materials that enhance the magnitude and duration of protective immune responses, typically via pattern recognition receptors (PRR). 2E151 is a co-adjuvant that increases the potency of toll-like receptor (TLR) adjuvants and overall enhances T cell stimulation/proliferation and cytokine production.1 It increases intracellular Ca2+ via extracellular Ca2+ influx, leading to NF-kB activation (EC50 = 0.9 µM)2 via IKK/MAPK phosphorylation and NFAT translocation in B cells and monocytes. Chemical Name: N-[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]-4-(4-propylpiperidin-1-yl)sulfonylbenzamide