Page 5 - Scientific Library

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and influence numerous cellular functions. Together with mature RNAs and small molecules, mature miRNAs can induce forced reprogramming

The Notch signaling pathway plays a vital role in the regulation of asymmetric cell division, cell fate specification and proliferation. Mammals possess 4 different Notch receptors, referred to as Notch1,

In a previous post, I mentioned that the secretome is becoming a very hot topic in the world of proteome analysis, and even a crucial study subject. Today, I'd like go a step further and shed some

Hypoxia in tumors is closely associated with tumor aggressiveness and resistance to radio- and chemotherapeutic treatment. Therefore, reliable markers for hypoxia represent both valuable diagnostic markers

As cell biologist, when working in labs I have in the past witnessed several “X-files” in a flask of cells along my way: all cells of an established cell line are supposed to have the same genetic background

Following on from my previous post  in which I started to introduce a series of techniques to investigate the impact of miRNA expression on cell fate, let's take a look at the first one: miRNA detection

In this third post of the miRNA-related series, let's take a look at miRNA overexpression.

miRNA mimics

Short RNAs are very prone to enzymatic degradation. Novel chemical technologies now allow RNA stabilization

Following our series of posts on tumour microenvironment (TME) and the role of Cox-2/PGE2 signaling, I'd like today to focus on inflammation and immunity.

TME is a dynamic milieu influenced by numerous

Cancer research is increasingly focusing on the tumour microenvironment (TME). Several studies have shown that tumours depend on external signals for maintenance and expansion. It is therefore needed

Following on in our series on microRNAs (miRNA - Keys to open cell biology’s secret chamber) , in this post, we'll be taking a look at Antagomirs (which are also called anti-miRs or blockmirs). These

Cytokines and growth factors that are produced by or have an effect on adipocytes and related peptide neuro-transmitters are central players in hunger vs. satiety balance and in eating behavior (1).

Leading on from my previous posts (see below) exploring microRNA detection, overexpression and inhibition, this time, let's spend a moment on target detection.

miTarget databases

There are many online