SPY700-DNA is a bright far-red & non toxic live cell nuclear stain based on SPY™ dyes series. Its optimized structure allows quick labeling of DNA in live & fixed cells with high specificity and very low background. SPY700-DNA stains the nuclei of live or fixed cells without the need for genetic manipulation or overexpression of fluorescent proteins. Its absorbance and emission are similar to Cy5.5. SPY700-DNA enables multicolor imaging with SPY505, SPY555, SPY595, SPY650, SiR, GFP and mcherry. SPY700-DNA can be imaged with Cy5 filtersets but using a 700 nm LP emission filter is best. It can be used for widefield, confocal, SIM or STED imaging in living or fixed cells and tissue.