NAM-Driven 3D Cell Culture Innovation Part. 2

Plug-and-Play Humanised Models

AIM Biotech supports your transition from animal models to human-relevant in vitro systems with easy-to-use microphysiological platforms. Their solutions are designed to integrate seamlessly into your workflow while delivering high biological relevance.

Key Benefits of AIM microfluidic chips

• Long, easily injectable gel regions minimise leakage risk
• Gas-permeable materials replicate incubator conditions without pumps
• Multicellular co-culture for physiologically relevant models
• Fine control over gradients and flow dynamics

Explore AIM Biotech Platforms

organiX
Designed for larger tissue models such as biopsies, organoids, tumoroids and spheroids, organiX enables you to recreate complex tissue microenvironments often missing from standard organoid systems. This means more predictive tumour biology and improved translational relevance.

idenTx
A flexible microfluidic platform for multicellular 3D culture in discrete compartments, idenTx allows you to build controlled co-culture systems with confidence and ease. Rapid media exchange without over-aspiration ensures consistency across experiments.

Available formats:

• idenTx 3 Chip (up to 3 experiments per chip)
• idenTx 9 Plate (9 independent experiments)
• idenTx 40 Plate (40 independent experiments)

Advanced Blood–Brain Barrier Modelling

With BBBBoost, you can enhance barrier tightness and reproducibility in your in vitro BBB models. Combined with idenTx or organiX, you can recreate physiologically relevant human blood–brain barrier systems, supporting neurotherapeutic research and transport studies with greater confidence.

Human Blood Brain Barrier in vitro to assess neurotherapeutic drug transport and neurovascular function with AIM Biotech’s idenTx-based BBB co-culture model and the Nikon AX/AX R Confocal Microscope.

Bringing Flow Biology into Focus

Cellix enables you to study cell behaviour under realistic flow conditions, bridging the gap between static assays and in vivo biology.

VenaFlux Solutions, Mimic Human Blood Vessels

Designed for shear stress experiments, VenaFlux systems provide a fully integrated workflow combining pump, imaging and analysis software.

VenaFlux Solutions comprises different packages, and the VenaFluxAssay software integrates the microfluidic pump, microscope and camera, resulting in a complete automated high-throughput flow assay system for shear stress experiments.

This enables you to investigate vascular biology, thrombosis and inflammation in a controlled and highly reproducible environment.

Vena8 Fluoro+ and Vena8 Endothelial+ biochips
These microcapillary chips replicate arterial, venous and capillary environments, enabling detailed studies of blood–cell interactions and clotting mechanisms under flow.

The microcapillaries of Vena8 Fluoro+ and Vena8 Endothelial+ biochips resemble the arterial, venous and capillary blood vessesls where blood interaction with clotting factors can be studied in vitro under shear stress.

Microfluidic Solutions

Microfluidic solutions enable on-chip cell culture that replicates key physiological functions of living organs under controlled flow conditions. By connecting microfluidic chips to precision pumps and flow sensors, they ensure accurate delivery of media and reagents, allowing tight control of the cellular microenvironment.

As powerful tools for drug discovery, organ-on-chip systems provide more predictive and human-relevant insights compared to conventional static models, supporting better decision-making in preclinical research.

Example of a organ-on-chip set up.

Microfluidic Set-Ups Tailored to Your Lab

Implementing organ-on-chip models doesn’t have to be complex. A typical setup includes:

• 1 x 4U Microfluidic pump (connected to vacuum and PC for SmartFlo control)
• 2 x Culture bottles (1 for culture media and 1 for waste)
• 1 x Flow Sensor
• Microfluidic chip suitable for organ-on-chip studies (VenaT4 or Vena8 Endothelial+)  
• Tubing and connectors for seamless integration

These systems are compatible with standard lab infrastructure, allowing you to scale experiments without major investment or workflow disruption.

Human-Relevant, Patient-Derived Models

SynVivo brings you closer to personalised medicine by enabling the use of patient-derived cells in advanced microfluidic systems. Their platforms replicate native tissue environments under dynamic flow, giving you real-time, predictive insights.

SynBBB™: Blood–Brain Barrier-on-a-Chip
Reconstruct the neurovascular unit with endothelial cells, astrocytes and pericytes under physiologically relevant flow conditions. SynBBB™ enables you to evaluate CNS drug transport, barrier integrity and neurovascular interactions with improved accuracy and reproducibility.

Download the flyer:  SynBBB

SynTumor™: Cancer-on-a-Chip Platform
Model tumour microenvironments with integrated microvascular networks, allowing real-time monitoring of drug penetration, immune cell infiltration and tumour–stroma interactions. Ideal for oncology research, combination therapy studies and personalised medicine approaches.

Download the flyer:  SynTumor Vascularized Cancer Models

SynALI™: Lung-on-a-Chip Platform
Simulate the human lung environment using an air–liquid interface system that supports epithelial differentiation, mucus production and ciliary function. A powerful tool for respiratory disease modelling, toxicology and inhalation studies.

Download the flyer:  SynALI Lung-on-a-Chip

SynRAM™: Inflammation-on-a-Chip Platform
Capture the complexity of vascular inflammation by integrating endothelial and immune cells under flow. Study adhesion, migration, cytokine release and barrier disruption in real time—supporting research in immunology and inflammatory diseases.

Download the flyer:  SynRAM 3D Inflammation Model

SynTox™: Multi-Organ Toxicology Platform
Perform advanced toxicology studies across multiple tissue types, including liver, lung, cardiac and vascular systems. SynTox™ enables more predictive safety assessment by replicating systemic responses in a controlled in vitro environment.

Download the flyer:  SynTox Toxicology-on-a-Chip

Why Choose These 3D Culture Platforms?

• Enhanced Physiological Relevance: Models that better mimic in vivo biology for disease research and therapeutic screening.

• NAM-Aligned Methodologies: Support ethical innovation by reducing dependency on animal models and extending predictive in vitro capabilities.

• Compatibility & Scalability: All systems fit standard lab infrastructure and integrate with imaging and automation workflows.

Ready to Advance Your Research?

Let our scientific team help you integrate the right 3D culture tools into your workflow.

• References

  Courtesy of AIM Biotech, Cellix, SynVivo.
  

Need Expert Guidance for Your 3D Disease Models?

Our scientific team at Tebubio supports you in selecting and implementing the most suitable microfluidic and organ-on-a-chip solutions, from advanced 3D co-culture systems to fully integrated microphysiological platforms tailored to your specific applications.

Benefit from personalised guidance to design robust, physiologically relevant models, optimise experimental conditions under flow, and generate predictive, high-quality data, helping you accelerate your research while confidently transitioning towards NAM-aligned, human-relevant in vitro approaches.