2',3'-cGAMP - 200 ug

Activity: Endogenous STING agonist . Function/Pharmacology: 2',3'-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3 Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol.4 DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.5 Chemical Name: Adenylyl-(3’5’)-2’guanylic acid, cyclic nucleotide, disodium salt