1,4-DPCA - 5 mg

Activity: Prolyl hydroxylase inhibitor . Function/Pharmacology: Potent inhibitor of prolyl 4-hydroxylase (IC50=2-4 μM)1. Inhibits collagen deposition via inhibition of collagen proline hydroxylation2,3. Subcutaneous injection of a 1,4-DPCA containing hydrogel into Swiss Webster mice that do not show a regenerative phenotype increased expression of HIF1α over 5 days. Multiple injections led to regenerative wound healing after ear hole punch injury4. Chemical Name: 1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid