UBE2A, His6 - 3.0 nmol

UBE2A is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. UBE2A is a substrate for cyclin-dependent kinase 2 with phosphorylation of Ser120, dramatically increasing ubiquitin conjugating activity.  During the cell cycle, peak phosphorylation of UBE2A coincides with peak ubiquitylation of histone H2B. Ubiquitylated H2B stimulates methylation of lysine 4 of histone H3. UBE2A and B are also involved in DNA lesion repair via recruitment of alternative polymerases to DNA. UBE2A has been implicated in regulating the ubiquitylation of aggregating proteins along with UBE2K and UBE2D2.