NMS-873 - 5 mg

Datasheet
p97 (aka VCP, Cdc48) is intimately involved in the ERAD process through the retrotranslocation of misfolded proteins targeted for degradation by the proteasome. It is a homohexamer of AAA₊ ATPase subunits and ATP hydrolysis is required for protein extraction from the ER. NMS-873 is an allosteric inhibitor of ATPase activity, binding to the D1 and D2 domains of adjacent subunits (Magnaghi, D’Alessio et al. 2013). NMS-873 is reported to have an IC50 for p97 of 20-30nM.

Supplier Catalog Number

 SI9752

Shipping conditions

 Cool pack

Storage Temperature

 -20°C

Supplier name

 LifeSensors

CAS Number

 1418013-75-8
From
NOK 3,500.00
Total NOK 3,500.00

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Additional information

CAS Number: 1418013-75-8
Application: Cell-based Assay