Fludarabine - 5 G

Fludarabine is a purine nucleoside derivative that disrupts ribonucleotide reductase and DNA polymerase in blood cells. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP, and survivin expression. Fludarabine displays anticancer activity against human hematological malignancies in vivo. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.