ENL YEATS Domain, Y78A, Recombinant Human - 100 µg

ENL YEATS Domain, Y78A, Recombinant Human (MLLT1, LTG19, YEATS1, accession Q03111, amino acids 1 to 150) containing an N-terminal 6xHis tag, expressed in E. coli. The ENL protein is part of the super elongation complex regulating RNA Pol II transcription. A chromosomal translocation resulting in an MLL-ENL fusion is involved in pediatric Acute Lymphoblastic Leukemia. The Y78A substitution ablates ENL YEATS domain binding activity.