ENL YEATS Domain, Recombinant Human - 100 µg

ENL YEATS Domain (MLLT1, LTG19, YEATS1, accession Q03111, amino acids 1 to 150) containing a C-terminal 6xHis tag, expressed in E. coli. The ENL protein is part of a super elongation complex (SEC) regulating RNA Pol II transcription, and a chromosomal translocation resulting in an MLL-ENL fusion involved in pediatric Acute Lymphoblastic Leukemia [1]. ENL YEATS Domain preferentially interacts with histone H3 crotonylated lysines over acetylated lysines [2].