Anti-Aquaporin 2 pS264 (RABBIT) Antibody - - 100 µL

Aquaporin 2 antibody recognizes aquaporin 2 (AQP2) which is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-264 has been identified as a novel phosphorylation site on AQP2 and shown to be regulated by vasopressin thus implicating this site as important in AQP2 trafficking and subcellular distribution. Anti-Aquaporin 2 pS264 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.