Anti-APC11 (C-terminal specific) (RABBIT) Antibody - - 100 µL

APC11 is also known as Anaphase promoting complex subunit 11, APC11, Cyclosome subunit 11, Hepatocellular carcinoma associated RING finger protein, and HSPC214.  APC11 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G₁ phase of the cell cycle. APC11 may function to recruit the E2 ubiquitin-conjugating enzymes to the complex.  APC11 interacts with the cullin domain of ANAPC2 and also interacts with UBE2D2.  APC11 shows both a cytoplasmic and nuclear localization.  APC11 is expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.  APC11 is a member of the RING-type zinc finger family and is auto-ubiquitinylated.