Anti-APAF1 (MOUSE) Monoclonal Antibody - - 100 µg

Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands.  Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.  The mammalian homologue of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1.  Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.  Apaf1 can also associate with caspase-4 and caspase-8.  Apaf1 transcript is ubiquitously expressed in human tissues. Anti-Apaf1 antibody is ideal for investigators that are involved in Apoptosis, Cytokine and growth factor research.