7-Cl-O-Nec1 - 5 mg

Activity: Rip1 blocker . Function/Pharmacology: Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5 Chemical Name: 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione