SPY650-tubulin is a bright, far-red & non toxic live cell microtubule stain based on SPYâ„¢ dyes series. Its optimized structure allows quick labeling of microtubules in live cells with high specificity and very low background. SPY650-tubulin stains microtubules in live cells without the need for genetic manipulation or overexpression of fluorescent proteins. Its absorbance and emission spectra are similar to Cy5. SPY650-tubulin enables multicolor imaging with SPY505, SPY555, SPY595, SPY700, GFP or m-cherry. SPY650-tubulin can be imaged with standard Cy5 filtersets. It can be used for widefield, confocal, SIM or STED imaging in living cells and tissue.