Research grade mRNA, saRNA, circRNA and polycistronic RNA by in vitro transcription (IVT), from sequence design and optimization through purification and quality control.
Tebubio provides custom RNA production and RNA synthesis services for research and preclinical applications.
Research grade (RUO) RNA is available from 100 µg to 10 mg, with RNA constructs up to 10 kb. RNA can be customized according to your experimental requirements, including 5′ capping, modified nucleotide incorporation, poly(A) tailing, and fluorescent labeling.
Our workflows support the production of:
mRNA
For short-term expression of various types of proteins.
saRNA
For high and long-lasting expression.
circRNA
For durable cap-independent expression.
Polycistronic RNA
For co-expression of multiple targets, including multi-antigen and multi-subunit applications.
From Design to Functional Validation: An RNA Workflow Tailored to Your Needs
We can support your project from RNA sequence design, codon optimization and DNA template preparation to IVT, purification and quality control, as well as with downstream delivery or expression studies.
Our workflows can be readily adapted to incorporate virtually any modification or reagent, including client-provided.
Sequence Optimization
- Plasmid and linear DNA
- Templates for mRNA, saRNA, circRNA and polycistronic RNA
- Enhanced protein expression
- Reduced immunogenicity
- Minimized truncated products
- 100 µg to 10 mg, up to 10 kb
- Choice of capping, modified and fluorescent nucleotides
- Various purification methods and quality controls
- Chemical transfection or LNP
- Encapsulation from 10 µg to 5 mg RNA
- Large choice of lipids, including conjugated
- Cell lines and primary cells 2D and 3D
- Uptake, delivery, expression
- Cellular response
- Functional activity
- Inflammation
- Plasmid and linear DNA
- Templates for mRNA, saRNA, circRNA and polycistronic RNA
- Enhanced protein expression
- Reduced immunogenicity
- Minimized truncated products
- 100 µg to 10 mg, up to 10 kb
- Choice of capping, modified and fluorescent nucleotides
- Various purification methods and quality controls
- Chemical transfection or LNP
- Encapsulation from 10 µg to 5 mg RNA
- Large choice of lipids, including conjugated
- Cell lines and primary cells 2D and 3D
- Uptake, delivery, expression
- Cellular response
- Functional activity
- Inflammation
DNA template
Choose our optimized templates for mRNA, saRNA, circRNA and polycistronic RNA, or provide your own.
Sequence optimization
Ensure enhanced protein expression and reduced immunogenicity while minimizing truncated RNA products.
RNA Production
Customize your RNA according to your research needs, including 5′ capping, modified nucleotide incorporation, poly(A) tailing, and fluorescent labeling.
Customize Your RNA for Your Research Application
Research Grade (RUO) RNA quality
RNA production from 100 µg to 10 mg, supporting early research and preclinical workflows.
5′ Capping
Select the appropriate capping strategy for your RNA construct and downstream application.
Modified Nucleotides
Incorporate modified nucleotides such as pseudouridine according to your experimental requirements to make your RNA more stable and improve its translation.
Poly(A) Tail
Customize poly(A) tail characteristics to support RNA stability and translation studies.
Fluorescent RNA Labeling
Use fluorescently labeled RNA, including options such as Cy5, for RNA tracking, uptake and localization studies.
Formulation in LNP
Select from a large library of lipids, including conjugated to fluorescent dyes and peptides, and get your RNA ready for delivery studies by encapsulation in lipid nanoparticles (LNP).
Cell validation
Characterize RNA delivery, uptake, expression and biological activity in relevant 2D/3D models, combining advanced imaging, functional assays and biomarker analysis to support functional proof-of-concept.
End-to-end solutions: from RNA to biological validation
Tebubio supports every stage of your RNA project with integrated solutions designed to streamline the transition from RNA production to in vivo applications.
Why Choose Tebubio for Custom RNA Production?
Why Choose Tebubio as Your Laboratory Service Provider
EXPERTISE
PhD-level expertise
Scientific guidance tailored to your research question.
FLEXIBILITY
Support at the right scale
From a single assay to a complete study, with solutions that evolve with your project.
SIMPLICITY
One partner, less complexity
From study design to results, with a dedicated project manager by your side.
ACCESSIBILITY
European expertise, global reach
Your research, handled in France, with close collaboration and support for researchers in Europe.
Scientific Resources
Explore how to optimize Lipid Nanoparticules for mRNA delivery for drug development.
This study highlights key formulation parameters: buffer composition, lipid selection; crucial for enhancing transfection and therapeutic efficacy.
Xavier Warnet PhD, our CRO's project manager published a review on how scientists have developed lipid nanoparticles (LNPs) that make it possible to deliver RNA in a more precise manner, paving the way for future development in oncology.
RNA Therapeutics
Cell Therapy
Biotherapeutic Discovery​
Choose Tebubio as Your Laboratory Service Provider
EXPERTISE
PhD-level expertise
Scientific guidance tailored to your research question.
FLEXIBILITY
Support at the right scale
From a single assay to a complete study, with solutions that evolve with your project.
SIMPLICITY
One partner, less complexity
From study design to results, with a dedicated project manager by your side.
ACCESSIBILITY
European expertise, global reach
Your research, handled in France, with close collaboration and support for researchers in Europe.