Scientific Library
Kupffer cells in co-culture models for liver inflammation studies
Kupffer primary cells are macrophages endogenous to the liver which have the ability to modulate hepatic inflammation and injury associated with various pathophysiologies and toxicities.
Tips and Tricks: how to increase unstable protein expression in E. Coli
Recombinant protein expression and purification for therapeutic development or for in vitro studies can sometimes be a real challenge. It requires huge investments in both time
New CryostaX® Rodent Hepatocytes - largest pools available, easy-to-use pellet format
Sekisui XenoTech have announced the addition of Rodent Hepatocytes to their patented CryostaX® product line.
The CryostaX® in vitro drug discovery and preclinical drug
Human Liver Lysosomes for in vitro catabolism testing
In this post, I'd like to introduce the Human liver Lysosomes developed by Sekisui-Xenotech, which have opened up a new era in catabolism models. Read on to learn more, and also to download a case study
Why you should outsource your production of proteins - both stable or unstable
Whether your protein is simple to produce, or complex and requires more development, in any case, outsourcing your protein expression, purification and production is a very viable option
Hepatic Hyaluronan Content increased by Alcohol Consumption in Patients with Liver Steatosis
In a previous post, I introduced Sekisui Xenotech's Research Biobank, which is based on rejections from liver transplantation as opposed to post-mortem tissues, thus offering a guarantee
Fully licensed SLC cell lines for FDA and EMA recommended transporters
In a previous post, we introduced our Ready-to-use cellular models for SLC assays by GenoMembrane.
These cell lines transiently express the current FDA and EMA recommended SLC
Hepatocyte Pellets - why should you make the switch?
You may have heard about the patented CryostaX® format of hepatocyte pellets, but do you know why SEKISUI XenoTech and countless other researchers have made
What is a clinical trial?
Clinical trials are the bedrock of medical research. They are conducted in distinct phases that we will detail in this article. But before clinical trials can even start, it is necessary to conduct preclinical
ELISA : Quality Control and Performance Evaluation
The ELISA test (acronym of Enzyme Linked ImmunoSorbent Assay) is a test principally used In immunology to detect and/or assay a protein, antigen or antibody in a biological fluid sample . It has many practical
What is the role of ADME in drug discovery?
ADME is an abbreviation in pharmacokinetics (a branch of pharmacology that studies how substances act and remain in organisms) for “Absorption, Distribution, Metabolism, and Excretion”.
Why are certain drugs called enzyme inhibitors?
Our bodies’ normal functioning relies on chemical reactions (for instance, the conversion of food into energy or the replenishment of cells in tissue, like in muscles or organs). These biochemical reactions