[KO Validated] RAG2 polyclonal antibody - 50ul

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Supplier Catalog Number

BS65018

Shipping conditions

Cool pack

Storage Temperature

+4°C

Supplier name

Nanjing Bioworld Biotech Co Ltd
From
€331.00
Total €331.00

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Additional information

Target Species: Human,Mouse
Host: Rabbit
Clonality: Polyclonal