BCMA antigen - 200uL

BCMA (B cell maturation antigen) is a type III membrane protein encoded by the TNFRSF17 gene and expressed on mature B cells and plasma cells. BCMA binding to TNFSF13B/BAFF results in activation of the NF-κB and MAPK8/ JNK signaling pathways. BCMA is highly expressed in malignant plasma cells and currently serves as an excellent therapeutic target for multiple myeloma. BCMA consists of 184 amino acids, and its GenPept accession number is NP_001183. ProMab’s PM-LNP-0121 nanoparticles contain an mRNA encoding BCMA protected by a lipid shell. The nanoparticles are formulated with SM102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery in vitro and in vivo.