4-1BBL mRNA-LNP - 200uL

4-1BBL (4-1BB ligand), also known as tumor necrosis factor ligand superfamily member 9 (TNFSF9), is a type II membrane protein expressed by T cells. Binding of 4-1BBL to its receptor 4-1BB (also known as CD137) provides costimulatory signals to the T cells, promoting cell proliferation and survival. 4-1BBL can also enhance TCR/CD3-triggered activation-induced T cell apoptosis, modulate CD28 co-stimulation to promote Th1 cell responses, and induce peripheral monocyte proliferation. 4-1BBL is comprised of 254 amino acids and its GenPept accession number is NP_003802. ProMab’s PMLNP-0060 nanoparticles contain the 4-1BBL mRNA protected by a lipid shell. The nanoparticles are formulated with SM-102, DSPC, cholesterol and DMGPEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery in vitro and in vivo.