Results for Cell Line ( 2021 )
Please note this product may be subject to fees, we invite you to contact your local office. The RARβ Reporter (Luc)-HEK293 cell line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARβ (accession # P10826-2).
Please note this product may be subject to fees, we invite you to contact your local office. The RARγ Reporter (Luc)-HEK293 cell line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARγ (accession #P13631-1).
Please note this product may be subject to fees, we invite you to contact your local office. The TEAD Reporter - MCF7 cell line contains the firefly luciferase gene under the control of TEAD responsive elements stably integrated into the human breast cancer cell line, MCF7. Inside the cells, basal unphosphorylated YAP/TAZ remains in the nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter by the activators of the Hippo pathway.
Please note this product may be subject to fees, we invite you to contact your local office. The NFAT Reporter - Jurkat Cell Line contains a firefly luciferase gene under the control of the NFAT response element stably integrated into Jurkat cells. This cell line has been validated for response to thapsigargin, ionomycin, and phorbol 12-myristate 13-acetate (PMA). It is useful as a control cell line for other NFAT reporter cell lines expressing various immune checkpoint receptors.
Please note this product may be subject to fees, we invite you to contact your local office. An NF-κB luciferase reporter construct is stably integrated into the genome of CHO-K1 cells. The firefly luciferase gene is controlled by the NF-κB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene. The NF-κB-luciferase / CHO-K1 cell line is suitable for monitoring the activity of NF-κB transcription factor through luminescence readout.). This cell line responds to human cytokine IL-1β, responds moderately to human TNF?, and does not respond to human IFN-λ (2 µg/ml). Reducing the amount of serum during incubation period may increase the sensitivity to cytokines. Since CHO-K1 cells do not express endogenous human proteins, this cell line provides an excellent platform to enable exogenous expression of a protein of interest to study its
Please note this product may be subject to fees, we invite you to contact your local office. NF-?B luciferase reporter construct is stably integrated into the genome of HCT-116 cells. The<br />firefly luciferase gene is controlled by 4 copies of NF-κ?B response element located upstream of<br />the TATA promoter. Following activation by stimulants, endogenous NF-κ?B transcription factors<br />bind to the DNA response elements to induce transcription of the luciferase gene. The NF-?κB-luciferase/HCT-116 cell line is suitable for monitoring the activity of NF-?κB signaling<br />in response to stimulants such as the cytokines TNF? and IL-1?β, pathogen-associated<br />molecular pattern (PAMP) (i.e. flagellin) or endogenous damage-associated molecular pattern<br />(DAMP) molecules (i.e. NOD1 ligand) (see application references). It is also suitable for<br />establishing cell-based screens for inhibitors that target specific NF-κ?B stimulating molecules.<br />This cell line can be further mo
Please note this product may be subject to fees, we invite you to contact your local office. CHO-K1 cell line expressing full length human CD27 (TNFRSF7). Expression is confirmed by real time qPCR and Western blot. Screening for antibodies recognizing CD27 and screening antibodies for binding affinities. Since<br />CHO-K1 cells do not express endogenous CD27, this cell line serves as an excellent model for<br />studying changes in CD27-mediated signaling pathways, such as NF-?B, MAPK and<br />SAPK/JNK.
Please note this product may be subject to fees, we invite you to contact your local office. NF-κB luciferase reporter construct is stably integrated into the genome of A549 cells. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.