Cell Line

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to academic organisations (not for profit).

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to private organisations.

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to academic organisations (not for profit).

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to private organisations.

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to academic organisations (not for profit).

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to private organisations.

The AC16 cell line, derived from human ventricular cells fused with SV40-transformed, uridine-auxotroph fibroblasts, showcases characteristics of cardiomyocytes, including the expression of transcription factors GATA4, MYCD, NFATc4, and contractile proteins like alpha- and beta-myosin heavy chain. These cells also express gap junction proteins connexin-43 and connexin-40, with functional gap junctions confirmed by dye-coupling studies. When the SV40 oncogene is silenced, AC16 transitions towards a differentiated state, marked by the expression of BMP2, indicative of cardiac differentiation. AC16 cells' ability to mimic cardiomyocyte behavior, including cessation of proliferation and formation of multinucleated syncytia under specific conditions, makes it a valuable model for cardiac research. It retains the genetic material of primary cardiomyocytes, allowing for studies on cardiac development and pathology in vitro, bridging gaps in understanding heart disease mechanisms and potential

Please note this product may be subject to fees, we invite you to contact your local office.

Please note this product may be subject to fees, we invite you to contact your local office.