Antibiotics & Metabolites

against mycobacteria

Aminoglycoside antibiotic

Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3 nM) with anti-cancer activity.

Antibiotic-5d is a synthetic antimicrobial compound. It exhibits moderate antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, fungi and yeast.

D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abiraterone is also an antagonist of androgen receptor.

N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.

Lurasidone metabolite 14326 hydrochloride is an active metabolite of the atypical antipsychotic Lurasidone.

Mebeverine alcohol is a metabolite of Mebeverine.

Niraparib metabolite M1 is niraparib metabolite, niraparib is a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.