Click Chemistry

t-Butoxycarbonyl-PEG8-Ala-Ala-Asn serves as a detachable PEG linker for crafting antibody drug conjugates (ADCs). It's a tripeptide susceptible to cleavage by proteases like legumain, a specific lysosomal enzyme.

Azido-PEG8-Ala-Ala-Asn, a distinctive peptide linker, features an azido group for facile reaction with DBCO, BCN, or similar alkynes through click chemistry. The PEG spacer enhances water solubility.

t-Butoxycarbonyl-PEG12-Ala-Ala-Asn, an essential component for antibody drug conjugates (ADCs), empowers the creation of water-soluble, cleavable ADCs, opening doors for innovative pharmaceutical designs.

Azido-PEG12-Ala-Ala-Asn, an exceptional tripeptide peptide linker, incorporates an azido moiety for effortless interaction with DBCO, BCN, or related alkynes using click chemistry. The included PEG spacer bolsters aqueous solubility.

Hemiasterlin (SC209) is employed in crafting antibody-drug conjugates (ADCs) targeting EGFR, enabling the development of precision therapeutics tailored for improved efficacy against specific cancer types.

Mal-Amido-PEG8-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide is a tripeptide PEG-attached ADC linker which may be cleaved by chymotrypsin. It features a maleimide to enable the covalent linkage to a biomolecule with a thiol and a terminal carboxylic acid for amine coupling.

Mal-PEG8-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide serves as a cleavable (by chymotrypsin) tripeptide linker, composed of a maleimide group to covalently bond with thiol groups, allowing biomolecule attachment, and a terminal carboxylic acid that forms stable amide bonds with primary amine groups using activators (e.g. EDC, or HATU).

H-Ala-Ala-Gly-OH is a tripeptide composed of two L-alanine units and one glycine, linked by peptide bonds. This molecule acts as a metabolite and is functionally related to L-alanine and glycine. Additionally, it can serve as a valuable linker in the development of antibody drug conjugates (ADCs).

SuO-Glu-Val-Cit-PAB-MMAE comprises a detachable ADC linker (SuO-Glu-Val-Cit-PAB) and a strong tubulin inhibitor (MMAE). This compound is pivotal in creating antibody-drug conjugates (ADCs) through synthesis. -80°C, protect from light The compound is unstable in solutions, freshly prepared is recommended.