Click Chemistry

DSG Crosslinker is a noncleavable crosslinker which is used in intracellular crosslinking due to its membrane permeability. DSG Crosslinkers contain two terminal NHS ester groups which are reactive toward primary amines. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Sulfo-Cy5-Tetrazine is a water soluable fluorophore linker bearing a tetrazine group for the TCO-ligation based labeling. This reagent has good aqueous solubility as well as stability in biological environments. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Trisulfo-Cy3-Alkyne is a water soluble cyanine linker containing an alkyne group, which enables Click Chemistry to attach trisulfo-Cy3 to various azide-bearing molecules. Trisulfo-Cyanine3 is a fluorophore which is compatible with a wide range of fluorescent scanners, imagers, microscopes, etc. It is a bright and photostable dye and can be easily detected in gels by naked eye in low amounts (nmol). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Trisulfo-Cy5-Alkyne is a cyanine5 linker with an attached alkyne group. The alkyne moiety can participate in copper-catalyzed Click Chemistry reactions with azides. Cyanine5 has excitation and emission wavelengths at 646/662 nm. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Trisulfo-Cy5.5-Alkyne is a cyanine5.5 linker with an attached alkyne group. The alkyne moiety can participate in copper-catalyzed Click Chemistry reactions with azides. Cyanine5.5 has excitation and emission wavelengths at 673/707 nm. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

MC-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.